Successful life cycle management of brands with leon’s MJR nanotechnology

Major advantages of nanotechnology-based drug formulations

The supergenerics market has developed in the current pharmaceutical world due to the desire for higher performing APIs coupled with the less stringent and time consuming reformulation (in terms of regulatory approval) required in re-innovating established drugs.

More than 60% of all medical drugs used worldwide show a poor solubility (BCS class II or IV, or the combination of both). These molecules are often difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues, including; poor bioavailability; lack of dose proportionality; slow onset of action and other attributes leading to poor patient compliance.

The use of nanotechnology can overcome and improve on a lot of these functionalities for both oral and parenteral delivery. This includes:

• Increasing the bioavailability of the drug – and possibly reducing dosage due to increased drug potency.
• Faster onset of action by increasing dissolution rate.
• Potential to switch from immediate release formulations to modified release formulations.
• Elimination of toxic solvents.

This webinar will discuss the “bottom-up” approach seen as the “next generation” approach in comparison to the “top-down” approach. Key advantages of the “bottom up” approach are:

• No thermical and no mechanical stress.
• Broad variety of substance classes
• Identical hardware for lab, pilot production and full market production (no scale up)
• No limits in capacity

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Quick Facts




3:00pm London
10:00am New York


60 Minutes

Hosted by

Business Review Webinars

Key Learning Objectives

Learn how using nanotechnology can enhance pharmaceutical drug development

A comparison of bottom-up-approach versus to top-down approach

Discover the advantage of the MJR technology compared to wet milling technology

Learn how to manage a complex drug delivery system using MJR technology

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