The pharmaceutical development of nanoparticle-based products, which encapsulate small molecules or large biomolecules, is a complex operation that has been met with various hurdles. From designing stable formulations to the critical task of scaling up to GMP-compliant manufacturing processes requires a holistic solution that can be relied upon. Current conventional technologies, fall short in addressing critical challenges in mitigating the risk of aseptic manufacturing, suboptimal product CQAs, high batch-to-batch variability, and steep production costs.
Recognizing the complexity of the emerging drug modalities, LEON has introduced the FR-JET® technology.
THE FR-JET® MODULAR MIXER
The FR-JET® Technology is based on jet-impinging principles and features a modular design with interchangeable parts. This innovative approach provides the flexibility to fine-tune process parameters from the early development stages through to large-scale production.
THE UNDERLYING PRINCIPLE
Two liquids are injected into the mixing chamber under pressure through two nozzles. This process establishes a highly turbulent yet stable mixing process, in which the liquids mix in a very short period of time within the mixing chamber.
The unique internal geometry of our mixer core maximizes turbulent mixing efficiency by minimizing the surface area-to-volume ratio and reduces deviations from ideal reactors by eliminating stagnant or dead volumes.
